Comparison of Linear and Nonlinear Algorithms for Detection of Cardiorespiratory Uncoupling in Endotoxemic Rats
DOI:
https://doi.org/10.17488/RMIB.40.3.6Keywords:
endotoxemic, oxytocin, cardiorespiratory coupling, ECG derived respirationAbstract
Previous studies have shown that LPS-induced endotoxemia causes a cardiorespiratory (CRP) uncoupling owing to the physiological effects of systemic inflammation. Also, it is known that oxytocin has anti-inflammatory effects and cardioprotective properties; however, it is unknown whether it can modify the CRP coupling. This study aimed to compare different linear and nonlinear mathematics methods for the detection of cardiorespiratory uncoupling between cardiac and respiratory time series. The R-R time series of electrocardiograms of male rodents that were administered with saline solution (V); lipopolysaccharide (LPS); oxytocin (O) and LPS + oxytocin (LPS + Ox) were studied. We tested the R-R and respiratory series derived from the electrocardiogram (EDR) for the four groups to quantify the degree of coupling with cross-correlation; cross sample entropy; conditional entropy; mutual infor-mation; and Rényi’s mutual information. We found that oxytocin does not seem to favor the CRP coupling during endotoxemia induced by LPS. Finally, we observed that the cross-sample entropy and the conditional entropy pre-sented the highest statistical differences to identify the CRP uncoupling produced by LPS.
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 I. M. Flores-Duarte, A. C. Pliego-Carrillo, C. I. Ledesma-Ramírez, J. C. Echeverría-Arjonilla, M. A. Peña-Castillo, G. Pacheco-López
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Upon acceptance of an article in the RMIB, corresponding authors will be asked to fulfill and sign the copyright and the journal publishing agreement, which will allow the RMIB authorization to publish this document in any media without limitations and without any cost. Authors may reuse parts of the paper in other documents and reproduce part or all of it for their personal use as long as a bibliographic reference is made to the RMIB. However written permission of the Publisher is required for resale or distribution outside the corresponding author institution and for all other derivative works, including compilations and translations.