Regenerative Medicine for Chronic Ulcers: Cutaneous Application of Mesenchymal Stem Cells of Wharton’s Jelly

Authors

  • A. Parra-Barrera Escuela Superior de Medicina del I.P.N. http://orcid.org/0000-0001-8631-3099
  • C. M. Mejía-Barradas Escuela Superior de Medicina del I.P.N.
  • C. C. Calzada-Mendoza Escuela Superior de Medicina del I.P.N.
  • E. Mera-Jiménez Escuela Superior de Medicina del I.P.N. http://orcid.org/0000-0002-7821-4012
  • A. L. Sánchez-Corrales Escuela Superior de Medicina del I.P.N.
  • G. Gutiérrez-Iglesias Escuela Superior de Medicina del I.P.N. http://orcid.org/0000-0002-4137-0652

DOI:

https://doi.org/10.17488/RMIB.40.2.1

Keywords:

regenerative medicine, mesenchymal stem cells, chronic ulcers

Abstract

Use of mesenchymal cells has emerged as an important part in regenerative medicine with positive effects in the recovery of damaged or lost tissues. Chronic ulcers include skin lesions that affect a large part of the population with diabetes mellitus, (for example, 9.14 develop diabetic foot according to ENSANUT 2016) and represent consi-derable economic expenses, due to poor quality of life in patients. The conventional treatment that is carried out in these cases is long term, and the generated beneficial effects that are presented are limited, since the injuries recur due to not having a specific and regenerative treatment, only palliative. That is why in this work they were obtai-ned and used mesenchymal stem cells derived from Wharton's jelly (MSC-WJ) under the criteria proposed by the International Society for Cell Therapy. The treatment was applied in two patients with chronic ulcers phlebostatic of different medical conditions and short-term monitoring, so it was a limited study. The results showed that MSC-WJ induced skin reconstruction by tissue formation granulation, in addition to decreasing the chronic inflammatory process in the area of damage, which favored the index of wound healing. Therefore, the use of MSC-WJ in chronic phlebostatic ulcers is proposed as a treatment in the regeneration of the tissue structure with short-term results.

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Published

2019-03-11

How to Cite

Parra-Barrera, A., Mejía-Barradas, C. M., Calzada-Mendoza, C. C., Mera-Jiménez, E., Sánchez-Corrales, A. L., & Gutiérrez-Iglesias, G. (2019). Regenerative Medicine for Chronic Ulcers: Cutaneous Application of Mesenchymal Stem Cells of Wharton’s Jelly. Revista Mexicana De Ingenieria Biomedica, 40(2), 1–11. https://doi.org/10.17488/RMIB.40.2.1

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Research Articles

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