Comparison between Mesenchymal Stem Cells obtained from Bone Marrow, Adipose Tissue and Wharton Gelatin according to the ISCT Criteria

  • A. Parra Barrera Departamento de Posgrado. Escuela Superior de Medicina Instituto Politécnico Nacional
  • X. Murúa Beltran García Departamento de QFBT. Universidad del Valle de México Campus Lomas
  • C. C. Calzada Mendoza Departamento de Posgrado. Escuela Superior de Medicina Instituto Politécnico Nacional
  • J. R. Cáceres Cortés Departamento de Posgrado. Escuela Superior de Medicina Instituto Politécnico Nacional
  • E. Reyes Maldonado Departamento de Morfología. Escuela Nacional de Ciencias Biológicas. Instituto Politécnico Nacional
  • G. Gutiérrez Iglesias Departamento de Posgrado. Escuela Superior de Medicina Instituto Politécnico Nacional
Keywords: Mesenchymal stem cell (MSC), bone marrow, adipose tissue Wharton’s jelly

Abstract

Mesenchymal stem cells (MSC) represent a heterogeneous population with the capacity to self-renew and differentiate into different cell types. At the middle of the last century these cells initially were described in bone marrow (BM), thence this tissue has become the gold standard for obtaining and characterization of MSC. It is known that these cells are housed in specific areas called niches distributed throughout all body, where they contribute to tissue regeneration processes of self-tissue were they are located. However, finding an alternative source of CTM with the same characteristics that have showed in MO, but its obtention no represent a risk since the donor is essential to their use for therapeutic purposes. In this study we isolated mesenchymal stem cells from bone marrow, adipose tissue and Wharton’s jelly and they were compared in their characteristics in according to the standards of the International Society for Cellular Therapy (ISCT). The results showed that the morphology as well as adipogenic and osteogenic differentiation and also the expression of surface antigens (CD90, CD73, and CD105) from all tissues accomplished the standards, although Wharton’s jelly represented the best option.
Published
2017-01-15
How to Cite
Parra Barrera, A., Murúa Beltran García, X., Calzada Mendoza, C. C., Cáceres Cortés, J. R., Reyes Maldonado, E., & Gutiérrez Iglesias, G. (2017). Comparison between Mesenchymal Stem Cells obtained from Bone Marrow, Adipose Tissue and Wharton Gelatin according to the ISCT Criteria. Mexican Journal of Biomedical Engineering, 38(1), 280-287. Retrieved from https://rmib.com.mx/index.php/rmib/article/view/31
Section
Special Issue