Preparación y Caracterización de Nanocompositos Quitosano-Cobre con Actividad Antibacteriana para aplicaciones en Ingeniería de Tejidos

K. Maldonado Lara; G. Luna Bárcenas; E. Luna Hernández; F. Padilla Vaca; E. Hernández Sánchez; R. Betancourt Galindo; J. L. Menchaca Arredondo; B. L. España Sánchez

doi:10.17488/RMIB.38.1.26

Preparation and characterization of Copper Chitosan Nanocomposites with Antibacterial Activity for Applications in Tissue Engineering

Authors

K. Maldonado Lara Departamento de Ingeniería Biomédica, Universidad de Celaya
G. Luna Bárcenas Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional
E. Luna Hernández Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional
F. Padilla Vaca Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato
E. Hernández Sánchez Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato
R. Betancourt Galindo Departamento de Materiales Avanzados, Centro de Investigación en Química Aplicada
J. L. Menchaca Arredondo Facultad de Ciencias Físico Matemáticas, Universidad Autónoma de Nuevo León
B. L. España Sánchez Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional

DOI:

https://doi.org/10.17488/RMIB.38.1.26

Keywords:

Chitosan, Copper nanoparticles, Antibacterial nanocomposites

Abstract

The present work describes the preparation of nanocomposites based on chitosan (QS)/copper nanoparticles (nCu) with antibacterial properties and potential application in tissue engineering. For this purpose, nanocomposites were prepared by solution blending with ultrasound assisted, aiming to increase the nanoparticles dispersion in the biopolymer. FTIR analyses demonstrates that nCu supported in QS increase their interaction of nanoparticles with amine/hydroxyl groups of QS molecule. UV-Vis analyses demonstrates that QS/nCu nanocomposites have an absorption signal associated with the presence of nanoparticles and the possible Cu2+ ions release in liquid media. AFM analyses shown that hydrated QS form a mesh with micro pores, improving the bacterial penetration and the direct contact with nCu. This behavior was corroborated by antibacterial assays, where QS/nCu nanocomposites shown an antibacterial activity higher than 90% between 90-180 minutes of interaction. Our results suggest that is possible to obtain combined antibacterial/biocompatible nanomaterials with potential application in tissue engineering.

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Published

2017-01-15

How to Cite

Maldonado Lara, K., Luna Bárcenas, G., Luna Hernández, E., Padilla Vaca, F., Hernández Sánchez, E., Betancourt Galindo, R., Menchaca Arredondo, J. L., & España Sánchez, B. L. (2017). Preparation and characterization of Copper Chitosan Nanocomposites with Antibacterial Activity for Applications in Tissue Engineering. Revista Mexicana De Ingenieria Biomedica, 38(1), 306–313. https://doi.org/10.17488/RMIB.38.1.26

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Issue

Vol. 38 No. 1 (2017): Enero - Abril

Section

Special Issue

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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